land cytology: 2012

Sunday, December 30, 2012

Russian Roulette

Looks can kill. Yet so can knives and daggers. And when the two are combined in a deadly masquerade, we shall see who comes out alive amidst the lies, secrets, and betrayal, who shall emerge victorious in this never ending death waltz.

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This topic is an Out Of Character part of the roleplay, ?Russian Roulette?. Anything posted here will also show up there.

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November Rain: Member for 0 years

This sounds fun. :) What will the gameplay be like? Political maneuvering, sneak/thief like, assassinations, etc. And will every player be in a different castle?

Malan: Member for 0 years

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Jill Brooke: Nora Ephron Taught Us How to Live and Die

In reflecting on all the people who passed away this year, I am thinking of Nora Ephron and how this witty, wise and loving woman taught us not only how to live but also how to die.

I last saw Nora Ephron earlier this year at the memorial for best-selling author Charla Krupp, who shocked her circle of loyal devoted friends by never divulging her terminal illness. While Nora was behind me as we signed our names on the guest book, a few friends, with tear rimmed eyes, came up to us questioning how anyone could keep a terminal illness secret or would want to make that choice. "We live in the age of the Internet where everyone tells everyone everything," cried one friend.

"The credit should go to a good marriage," I said, referring to Charla's partnership to Time magazine's theater critic Richard Zoglin. "How lucky was she that her husband's love was enough that she didn't need anyone else."

I then turned to Nora and for some inexplicable reason said, "Don't you agree?" In owl-like black sunglasses, the celebrated writer of romantic comedies like Sleepless in Seattle and When Harry Met Sally nodded her head and whispered, "That is so true." Only now I realize she most likely was thinking of her own husband, writer Nick Pileggi, whose quiet unwavering support gave her the protective cocoon to keep her secret intact -- even from her children.

As Frank Rich wrote in his New York Magazine piece about Ephron, people have legitimate reasons to want to keep pending death a secret. He said his friend may have not wanted "her illness to change the weather in any room she entered. She did not want to spend every day fending off an onslaught of concerned questions. She didn't want to be thought of as a lesser person. She did not want friends to see her falling apart."

Rich went on to share how at Ephron's memorial in New York City, her son Max Bernstein reflected on his mother's unexpected gift for not divulging the seriousness of her illness.

"I think that she just kept quiet so the rest of us could keep enjoying being with her as much as possible," Max said at the memorial. "All of those moments would have been bittersweet or sanctimonious, flanked by an asterisk, leading to a footnote that says, "There aren't many of these left." Then he added, "I am so glad they weren't that way."

But it couldn't have been that way for Max or his brother Jacob without Nora's husband Nick Pileggi by her side. Yes, this man who she married in 1987 was a good fella in the best of ways.

As a culture, we often focus on the lust and laughs of new marriages. But want to see passion at its sexiest? For me, it is witnessing the long-term marriages of couples whose passion for loyalty and the respect for their history together endures so that each spouse can feel safe and not judged during times of weakness. Long term marriages are the real love stories of our time. Just wish there were more of them.

Lucky Nora had Nick to discuss the challenges of squeezing joy from life with rationed time. She had him to give her the chicken soup when treatments made her sick and cranky. She had him to cry with at night when the fear of the unknown choked her with anxiety. Nora had Nick to soothe her apprehensions so her public face could still be smiling. So she could still be working. So she could still be living the life she wanted. So she could be, as she often said, "the heroine of your life, not the victim."

Friends of course lamented not being able to say farewell. But as Bruce Feiler wrote in the New York Times, farewell conversations are usually awkward and forced. What do you say after goodbye? Sorry this happened and it sucks? As I've witnessed, the dying often feel obligated to make their friends feel better about their condition. It becomes stressful for them. They only feel safe with a trusted few.

Oddly enough, Nora Ephron, the woman who eagerly doled out delicious recipes for Thanksgiving dinners, never did share the one recipe many covet: The recipe for a loving devoted marriage. With the divorce rate hovering towards 50 percent, few will have built a reservoir of good times to not need anyone else when the end of life comes.

In fact one of Nora Ephron's greatest successes ends up proving not only that in divorce, wife can go on, but that she can marry well too.

Follow Jill Brooke on Twitter: www.twitter.com/divorcemama

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Source: http://www.huffingtonpost.com/jill-brooke/nora-ephron-taught-us-how_b_2382504.html

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STEVE VAI Endorses MOTION DEVICE Keyboardist's Cover Of 'For The Love Of God' On Facebook

In the clip below, MOTION DEVICE's 15-year-old Andrea Menoudakis covers legendary guitarist STEVE VAI's 'For The Love Of God' on piano. Vai has posted the clip on his official Facebook page in support of Menoudakis' performance.

Check it out below along with Vai's original recording of the track:

For information on Motion Device go to this location.

Source: http://www.bravewords.com/news/196221

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Saturday, December 29, 2012

Critics: Myriad blocks cancer answers by impeding data sharing ...

Patents ? Utah company says it has aided, not hindered, research, care.

Tory Galloway thought her negative result on a widely-used test sold by Utah-based Myriad Genetics Inc. cleared her DNA as a cause for her fallopian tube cancer.

She happily advised her four sisters that the disease didn?t result from a family trait. The relief from the December 2010 test, though, was short lived. In October, after getting results from a broader scan at the University of Washington that included dozens of genes, she learned the truth: Her cancer was caused by a mutation that wasn?t included in the Myriad product.

"It makes me nuts to even think about it," said Galloway, a landscape designer in Indianola, Wash.

The broader test, created by University of Washington researchers, uses technology to identify as many cancer risks as possible. There?s one problem: Such a test can?t include the BRCA1 and BRCA2 genes that are the most common inherited causes for breast and ovarian cancer because Myriad owns the patents on them. This prevents other U.S. laboratories from using them in a commercial test.

In the mid-1990s, Myriad helped kick-start the gene-testing revolution by pinpointing the two BRCA genes. Now, the world?s biggest genetic testing company for breast cancer, with a market value of $2.2 billion, is under attack by researchers, genetic counselors, doctors, and their patients.

Besides stifling competitors from offering combination tests, including the BRCA genes, critics also said the company won?t share data from decades of testing that could aid research into how best to interpret screening. They said Myriad doesn?t adequately respond when other researchers find added BRCA mutations that address risks their current tests don?t cover.

"What is at stake is the way we want our health-care system to work," said Robert Cook-Deegan, a professor of public policy, biology, and medicine at Duke University in Durham, North Carolina, who supports limits on gene patents. "The testing has been set up by Myriad to optimize this business model. It is not set up to optimize public health outcomes."

The dispute, which has grown in intensity as more and more cancer-causing mutations are found, has spilled out of the laboratories and clinics into the U.S. Supreme Court. A ruling next year in a case challenging Myriad?s hold on the BRCA patents could either support the company?s profit-driven motives or redefine a nascent industry in a way that affects millions of dollars in revenue.

Myriad officials reject the criticisms, saying they offer faster, more accurate testing for harmful mutations in breast cancer genes than any other laboratory in the world, and that its patents haven?t hindered research or patient care.

"Myriad has never done anything to harm patients," CEO Peter Meldrum said during an interview at his company?s headquarters in Salt Lake City. "We have the most accurate results, we give the fastest results." There has never been a reported case in which Myriad wrongly told that a woman she had a cancer-causing mutation, he said.

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Carol Mackoff, 70, a Chicago-based managing director for Rice Financial Products Co., says Myriad "saved my life."

Mackoff tested positive on a Myriad test for a BRCA1 mutation in 2002 after visiting an ovarian cancer prevention program at Northwestern Memorial Hospital in Chicago, she said in a telephone interview. Within weeks, she had her ovaries removed to prevent ovarian cancer, and later in 2009 had a prophylactic double mastectomy.

Without the Myriad test, "I would have had cancer," she said. "The fact that they developed these tests and gave me a tool to work with to allow me to prevent getting cancer, I owe them everything."

Faster, cheaper DNA testing is revolutionizing medical care. Nowhere has the impact been felt more strongly than in breast cancer. A woman who tests positive using Myriad?s tests carries as much as an 80 percent chance that she will get breast cancer in her lifetime. Testing helps women take charge of their medical future, providing options that can include preventative surgery and more extensive monitoring.

Widespread use of the tests has made Myriad an unabashed financial success. The company?s testing business, led by its flagship $3,340 BRCA product, carries an 87 percent gross profit margin that in fiscal 2012 generated $496 million in sales, according to Myriad.

That?s helped boost the company?s shares 30 percent this year.

Next Page >

Source: http://www.sltrib.com/sltrib/money/55537762-79/myriad-cancer-test-brca.html.csp

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Alleged militants detained in Djibouti charged by US court

WASHINGTON (Reuters) - In a sign of evolving U.S. legal tactics in counter-terrorism operations, two Swedish citizens and a former British citizen detained in Africa in August have been charged in a U.S. court with supporting Somali-based Islamist militants.

The charges were filed in Federal Court in Brooklyn, New York, even though court papers and a press release from the U.S. Attorney's office make no specific allegation that the three - all of whom are of Somali extraction - posed threats to Americans or U.S.-related targets.

The three suspects - two Swedish citizens and a former London resident whose British citizenship recently was revoked - were charged with supporting the militant group al-Shabaab, illegal use of high-powered firearms, and participating in what prosecutors called "an elite al-Shabaab suicide-bomber program."

Ephraim Savitt, a former federal prosecutor who represents one of the Swedish defendants, said he was unaware of any secret evidence that the men threatened U.S. interests, and he saw "no prosecutorial hook whatever to the United States."

Savitt said he was unaware of any previous case in which U.S. authorities had taken custody of foreign militants who had no obvious connection, and posed no known threat, to U.S. interests.

However, a U.S. law enforcement source said there had been cases in the past where suspected foreign militants arrested overseas who had not directly threatened the United States had been brought before U.S. courts on terrorism-related charges.

The latest suspects - Swedes Ali Yasin Ahmed and Mohamed Yusuf, and former British resident Madhi Hashi - were detained by local authorities in Africa in early August while on their way to Yemen, the statement from prosecutors said.

The suspects were subsequently indicted in October by a Brooklyn-based federal grand jury, and in mid-November the FBI "took custody" of them and brought them to Brooklyn, where a revised indictment was filed against them, prosecutors said.

No information about the case was made public until just before Christmas, however.

U.S. officials said they were unable to provide further details about where the suspects were originally arrested, who arrested them, what was the legal basis for their initial arrest, and what happened to them between early August and their first known public court appearance in late December.

ARRESTED IN DJIBOUTI

However, Savitt, who represents Yusuf, said the men were arrested in Djibouti on their way to Yemen.

He said that at one point the men had been "fighters" with al-Shabaab, a group the United States has linked to al Qaeda. But at the time of their arrest, Savitt said, the men were trying to get away from the group after an apparent falling out.

Savitt said he did not know why they were heading to Yemen.

Saghir Hussain, a British lawyer who represents the family of Hashi, told the BBC this month the case had the "hallmarks of rendition," a reference to a secret procedure adopted by the U.S. Central Intelligence Agency during the administration of former President George W. Bush.

Such renditions involved teams of agency operatives taking custody of suspected militants overseas and handing them over, without legal process, to third countries, where they were sometimes mistreated.

Neither Hussain nor Harry Batchelder, Hashi's American lawyer, responded to messages requesting comment. Susan Kellman, a U.S. lawyer for Ahmed, also could not be reached.

Savitt said Hashi and the other suspects were detained and held in Djibouti by local authorities, who sometimes treated them roughly, but U.S. officials who at one point were allowed to interrogate them were "civil."

U.S. government sources familiar with the case said it could not be considered a "rendition," as in such cases suspects were not brought into the U.S. criminal justice system.

President Barack Obama's administration has declared it has stopped counter-terrorism practices such as "enhanced interrogations" and the use of secret CIA prisons, but it has not completely renounced the use of "rendition."

Hashi's family told the BBC that earlier last summer they received a letter from Britain's internal security department, the Home Office, declaring that his British citizenship had been revoked as he was deemed a threat to the U.K. security.

Under British law, Hashi had a right to appeal the revocation of his citizenship to an immigration court. A spokesperson for the British Embassy in Washington said that, for legal reasons, the government could not comment on whether or not such an appeal had been filed.

Source: http://news.yahoo.com/alleged-militants-detained-djibouti-charged-us-court-082452125.html

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Laws That Every Freelancer Should Know | The Work at Home Woman

Laws That Every Freelancer Should Know By Leon Harris

Anyone who has done the self-employment shuffle will agree that this manner of earning an income is a mixed bag, just like most other jobs. There are certainly some major benefits to working for yourself; you can skip the commute, you get to be your own boss, and you can set a flexible schedule and take vacations whenever you want.

On the downside, you have to hustle for work, you don?t get benefits, and you lack some of the many protections that employees under the corporate umbrella enjoy. As a freelancer, you?ll also face a very different set of legal issues than your 9-to-5 counterparts. And what you don?t know could definitely hurt you.

So here are just a couple areas of the legal landscape that you?ll want to address as soon as possible.

First and foremost, you need to protect yourself.

Without the shelter of a company to hide behind you could find your personal assets on the auction block should you land in a lawsuit. You might not think this is possible; after all, it?s not like someone is going to slip and fall on your front steps (especially if you are smart enough to meet clients elsewhere rather than having them come to your home). But suppose a client or content creator sees your work and decides that you have engaged in plagiarism, copyright infringement, or patent theft. They could certainly take you to court to hash it out. Or if a client determines that you provided shoddy work and they have already paid you, they are well within their rights to come after you for reimbursement.

For these reasons it?s not a bad idea to consider forming an LLC (limited liability corporation) or an S-corp.

As an employee or shareholder of a corporate entity you can receive pay without being held personally liable in situations where the company is sued. This means that personal assets like your home and bank accounts will not be subject to seizure in the event that you lose a lawsuit. Only the assets held by the company can be taken (and if you pay out the majority of earnings to yourself, the losses will be minimal).

You also need to consider making a general contract for doing business.

Although many clients may have their own contracts in place for freelance workers (often including clauses like NDAs and such to protect their proprietary information), these documents are not designed with your best interests in mind. In truth, a basic contract for work could be as simple as a purchase order with the job to be done and the pay to be given. But if you have further legal concerns, such as wanting to retain the right to use anything you produce in the promotion of your business, for example, you need to spell it out in the contract so you have a legal leg to stand on if it comes to that.

Finally, there are tax laws that pertain to self-employed persons.

For example, you?ll need to be aware of regulations regarding deductions, which are a saving grace when it comes to filing your annual income tax. As a freelancer you may claim all kinds of write-offs for your business, like a home office or work vehicle, travel expenses, business meals, equipment and supplies, and even research and development, just for example. But you don?t want to raise any red flags and bring an audit down on your head, so it?s important to know exactly what you are allowed to claim. You might never have to hire an accident or injury attorney in your line of work, but if want to avoid legal issues that are likely to plague freelancers, you first need to be aware of potential lawsuits and then work to protect yourself within the limits of the law.

Leon Harris is a contributing writer for Hornsby Law, the premier slip and fall attorney Atlanta.

Friday, December 28, 2012

Years later, new owners still owe for old transgressions ? Business ...

Townsend Oil and Propane bought Nichols Oil & Gas in Macedon seven years ago. Turns out, the company also bought liability for harassment committed more than a decade ago by the former owner.

Under the terms of a just-reached settlement, Townsend must pay $150,000 to women who claim they were sexually harassed by the man who owned and ran Nichols Oil & Gas.

According to the women?s complaint to the EEOC, the owner routinely grabbed their breasts and buttocks and lewdly propositioned them. Although the incidents occurred between 1999 and 2003, they weren?t settled until earlier this year. Nine women filed EEOC complaints before the company was sold in 2005.

The court judged Townsend Oil & Propane, as the new owner, an ?innocent purchaser? that was nonetheless a ?successor defendant? liable for the harm the women suffered.

Note: When purchasing a business, always ask about pending complaints or litigation.

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Source: http://www.businessmanagementdaily.com/33477/years-later-new-owners-still-owe-for-old-transgressions

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Fiscal cliff? Here are ways to cushion your fall.

Higher taxes and federal spending cuts would begin to hit all Americans Jan. 1. Here are ways to cope with the 'fiscal cliff.'

By Christianna McCausland,?Correspondent / December 27, 2012

Hundreds of veterans and military spouses meet with prospective employers at the Hiring Our Heroes DC job fair at Nationals Park earlier this month in Washington. Failure of 'fiscal cliff' talks would lead to mandatory budget cuts and cun employment by some 2.1 million jobs, according to one estimate. Hardest hit would be Maryland and Virginia, with large concentrations of federal workers and those who work for contractors to the US government.

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The "fiscal cliff" ? that perfect storm of mandatory budget cuts, expiring tax cuts, and new taxes ? looms with all the finality of a New Year's countdown clock.

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Unless Congress acts by Jan. 1, $600 billion to $800 billion would be cut from the federal deficit. Such a cut ? about 20 percent of federal spending ? dwarfs any reduction since 1947, when the United States was winding down wartime spending. Even if Congress reaches a compromise, Americans are sure to feel the pinch at some point.

"The drain of this money from the private economy may mean a serious economic slowdown, as if the economy ran into a wall," says Mark Waldman, a financial adviser in Vienna, Va., and executive in residence at American University.

Here are three ways to mitigate the effects of going off the cliff:

1. Taxes: The fiscal cliff comprises several tax changes, including the expiration of Bush-era and payroll tax cuts, and the introduction of new taxes to pay for Obamacare. That would amount to more than a $500 billion tax increase, according to the Urban-Brookings Tax Policy Center. Will Congress ring in 2013 by dunning each household an average of nearly $3,500?

If taxes are likely to go up next year, it makes sense to take as many tax breaks as you can and pay as much tax on income this year as you can. Of course, there's bound to be plenty of uncertainty over which taxes will go up. That means market volatility, says?Peter Hayes, managing director and head of BlackRock's municipal bond group in Princeton, N.J. "Take advantage of any overselling or overbuying that occurs."

Mr. Waldman is less optimistic. "Anyone who's not scared doesn't understand the problem," he says. He recommends short- to intermediate-term bonds, so a sudden rise in interest rates wouldn't hit so hard, he says. "In stocks, the safest place to be is in world-leading, dividend-increasing companies, large multinational firms that not only [pay] dividends every year but increase them."

Households should cut expenses, he adds. Set aside a rainy day fund if you don't have one yet.

2. Employment: Mandatory budget cuts would cut equally into defense and nondefense jobs. A George Mason University report estimated that the cuts would trim the nation's gross domestic product by $215 billion and cost 2.14 million jobs.

"We're already seeing a reduction in hiring, an increase in layoffs, and a cautiousness across the federal contracting community," says Jenessa Hoffman, president of Potomac Recruiting in Arlington, Va. With so many federal contractors, Maryland and Virginia have the most to lose, but spending cuts would hit nationwide.

Many jobs could be at stake, so update your r?sum?. "You never know when you're going to meet someone who provides an opportunity, and you don't want to spend a weekend pulling your r?sum? together," says Ms. Hoffman. Participate on social networking sites to boost visibility. Consider job havens like IT and health care.

3. Health care: If the 2 percent cut in Medicare goes through, 496,000 jobs would be lost in the first year, says a report by the American Medical Association (AMA), the American Hospital Association, and the American Nurses Association. That hits communities as well as facilities.

There are access concerns, too: "Medicare payments to physicians have been frozen for the last 10 years while practice costs have gone up," says Jeremy Lazarus, AMA president. "This kind of cut could impact physician decisionmaking about seeing new Medicare patients."

Strategies to avoid Medicare cuts are limited. Mr. Lazarus suggests that the public put pressure on Congress to repeal the cuts and eliminate the current formula that would lower Medicare payments an additional 27 percent. Others suggest a wholesale reform of the Medicare system.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/hpfM8F1KG9g/Fiscal-cliff-Here-are-ways-to-cushion-your-fall

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Ability to Metabolize Tamoxifen Affects Breast Cancer Outcomes ...

For nearly a decade, breast cancer researchers studying tamoxifen hormone therapy have been divided as to whether genetic differences in a liver enzyme affect the drug?s effectiveness and the likelihood breast cancer will recur. A new study by researchers from the Mayo Clinic Cancer Center provides evidence that genetic differences in the enzyme CYP2D6 play a key role in how well tamoxifen works.

?Our findings confirm that, in early breast cancer treated with tamoxifen, genetic alterations in CYP2D6 lead to a higher likelihood of recurrence and death,? says Mayo Clinic oncologist Matthew Goetz, M.D., lead author of the study in the journal Clinical Cancer Research.

In the clinical trial, Dr. Goetz and his colleagues studied the rates of cancer recurrence and death in two groups: postmenopausal women with primary estrogen receptor-positive breast cancer who received tamoxifen for five years and those who received tamoxifen for two years followed by the aromatase inhibitor anastrozole for three years. Anastrozole is a breast cancer drug whose metabolism does not require the CYP2D6 enzyme.

The study showed that women who were born with genetic alterations of CYP2D6 that abolish the enzyme?s critical metabolizing activity and who took tamoxifen for five years had recurrence of breast cancer, or died at a rate 2.5 times higher than women with normal CYP2D6 enzyme activity. Women with intermediate levels of the CYP2D6 enzyme had rates of recurrence or death 1.7 times higher than women with normal CYP2D6 activity. Importantly, Dr. Goetz notes, that genetic alterations in CYP2D6 did not affect the likelihood of recurrence or death in women who switched to anastrozole after two years of tamoxifen.

?Switching from tamoxifen to an aromatase inhibitor may be one reason for the discrepant studies surrounding CYP2D6 and tamoxifen -- as information about whether a patient took an aromatase inhibitor after tamoxifen was not available in most of the prior studies,? says senior author James Ingle, M.D., of Mayo Clinic, an expert on hormone therapies for breast cancer.

A blood test can determine whether a woman has alterations in CYP2D6 and predict how efficiently her body will convert tamoxifen to endoxifen. Approximately 5 to 7 percent of European and North American populations are considered poor metabolizers of tamoxifen.

?The results of this successful high-level international research collaboration are an important step forward in our quest to individualize breast cancer treatment and provide tailored care to women with breast cancer,? says Michael Gnant, M.D., professor of surgery at the Medical University of Vienna and president of the Austrian study group.

So what should a woman do if she is unable to effectively metabolize tamoxifen into its most active form? Dr. Goetz believes that the current recommendation of switching from tamoxifen to an aromatase inhibitor is likely to result in the greatest benefit in women with decreased CYP2D6 metabolism. For CYP2D6 poor metabolizers, avoiding tamoxifen altogether and starting out with an aromatase inhibitor may be the best approach, he says.

Dr. Goetz?s group is working with the National Cancer Institute to develop endoxifen as an alternative to tamoxifen. If women can be given endoxifen, the active part of tamoxifen, it won?t matter how tamoxifen gets metabolized, he says.

Article: CYP2D6 Metabolism and Patient Outcome in the Austrian Breast and Colorectal Cancer Study Group Trial (ABCSG) 8 Matthew Goetz et al. Clinical Cancer Research, 10.1158/1078-0432.CCR-12-2153

Source: http://www.sciencecodex.com/ability_to_metabolize_tamoxifen_affects_breast_cancer_outcomes-104422

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Monday, December 24, 2012

Dealing With Hemorrhoids: What To Do Today - Health Care

A lot of women who become pregnant get hemorrhoids about six months into their pregnancy. This is because the developing fetus places a greater degree of pressure on the blood vessels in the rectal area. Often, the strain of pushing throughout labor can cause the hemorrhoids to worsen. The information contained in this article will help to prevent and/or treat hemorrhoids.

Give some natural remedies a try before you spend money on pricey hemorrhoid treatments. Spend about fifteen minutes relaxing in a sitz bath. This is especially helpful following a bowel movement. Never scratch your hemorrhoids, no mater how much they itch, because this can aggravate the condition. One alternative to scratching is using a pad with a bit of witch hazel, apply this to the area to get some relief from the hemorrhoid itch. Try to eat a good amount of fiber, and drink plenty of water every day. This will help prevent excessive straining during your bowel movements.

Avoid scratching and irritating your hemorrhoids no matter what. The relentless itchiness of hemorrhoids during a flare-up can be maddening. It can be relieving to scratch your itchy hemorrhoids but this will just cause them to become irritated and heal slower. Instead, look for medicated products or homeopathic remedies to provide itch relief.

A few foods that can help treat hemorrhoids are nuts and seeds that don?t contain salt, fruits, whole grain breads and cereals. A simple, balanced diet will drastically improve your condition.

Hemorrhoids that are not unusually large can typically be pushed back inside the body, however, this should be done quite gently. You?ll find that it makes the situation much more comfortable while you sit, also reducing the chances of the hemorrhoid getting worse. Just be sure to push in gently, and never act in a forceful manner.

Witch Hazel

Witch hazel is an effective remedy for pain and irritation associated with hemorrhoids. Witch hazel is an astringent that will shrink or constrict the hemorrhoid tissue, bringing relief and healing. Either use a cotton ball to apply it for 5-10 minutes, or mix it with a sitz bath.

An excellent method of preventing hemorrhoids is performing exercises for the anus. If you are not exercising your anus muscles, you may lack blood flow to the area, which may result in you getting hemorrhoids. You should aim to flex your anus?s muscles for approximately five minutes every three or four hours. Hold this flex for approximately five seconds before you release it.

Some people have discovered that slices of tomatoes can assist with shrinking the dimensions of hemorrhoids. Since tomatoes contain a mild acid, applying slices of the produce to your swollen hemorrhoids is an effective method to reduce swelling. Combine this simple remedy with sticking to healthy foods and your problem may be solved.

Losing Weight

Losing weight will help decrease hemorrhoid pain. If you are overweight, you can experience more issues with hemorrhoids. Extra weight puts a lot of strain on your lower body, including your anal veins. Try losing weight by following a plan that uses high fiber foods, so that it can reduce your body?s pressure. Be careful not to utilize laxatives as a method of weight loss or as a hemorrhoid treatment, because it is unsafe to do so.

If hemorrhoids are bugging you, relief might just be in sight. It is suggested that you sit in a sitz bath several times a day, for about 10 minutes each time. Use a cold compress on the affected area, too.

Hemorrhoid pads are great for hemorrhoids. These pads provide a safe topical treatment for anyone to use.

As previously stated, hemorrhoids are common during the last six months of pregnancy, and pushing during labor can make them worse. There are many ways to prevent them from forming. If you master the advice in this piece, you stand a good chance of lessening the frequency of hemorrhoid flares.

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Iranian exiles blame Iraqis for camp death

BAGHDAD (AP) ? An Iranian exile group representing residents of a refugee camp outside Baghdad alleged Monday that one of its members has died after Iraqi authorities prevented him from being hospitalized last month.

The allegation is the latest in a series of charges against the Iraqi government by the Paris-based National Council of Resistance of Iran over what it sees as poor treatment at two refugee camps in Iraq.

Members of the NCRI's Mujahedeen-e-Khalq militant wing, which until recently was labeled a foreign terror organization by Washington, began moving from their longtime home at Camp Ashraf in northeast Iraq to a new camp close to the Iraqi capital's airport earlier this year.

The Baghdad-area camp, a former American military base known as Camp Liberty, is meant to be a temporary way station while the United Nations works to resettle the residents abroad. They are unlikely to return to Iran because of their opposition to the regime.

Behrooz Rahimian, the 56-year-old resident who died, was staying at Camp Liberty when he began complaining of chest pains on Nov. 25, according to a statement by NCRI spokesman Shahin Gobadi. He was taken to a Baghdad hospital, but Iraqi authorities intimidated doctors there, and he was soon taken back to Camp Liberty after being given medicine, the group alleges.

Rahimian died of cardiac arrest on Sunday, the NCRI said. The group blames his death on Iraqi officials' refusal to keep him in the hospital, and it criticizes the United Nations mission to Iraq for not taking what it sees as sufficient steps to intervene.

Iraqi Human Rights Minister Mohammed Shiyaa al-Sudani told The Associated Press he would launch an investigation into the issue and "find out the problem if there is any." He noted that there are monitors on site to ensure residents are receiving adequate treatment.

"Their claims are endless. We have two teams at Camp Liberty ? one from the U.N. and another from my ministry ? to offer them all the services they need according to the U.N.'s standards," he said.

The U.N. is aware of Rahimian's death, and its human rights monitors are trying to establish the facts in the case, Baghdad-based spokeswoman Anne Czichos said.

Iraq's government is eager to have the MEK out of the country. The group, which is also called the People's Mujahedeen of Iran, opposes Iran's clerical regime and carried out assassinations and bombings in Iran until renouncing violence in 2001.

Labeled by some as a cult, it fought in the 1980s alongside Saddam Hussein's forces in the Iran-Iraq war. Several thousand of its members were given sanctuary in Iraq by Saddam.

Iraq's current Shiite-led government, which has close ties to Iran, considers the MEK a terrorist group and says its members are living in Iraq illegally. Iraqi security forces launched two deadly raids since 2009 on Camp Ashraf, a small city near the Iranian border that the exiles never wanted to leave.

The Obama administration took the MEK off the U.S. terrorism list in late September. Canada did the same last week.

___

Associated Press writer Qassim Abdul-Zahra contributed reporting.

___

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Source: http://news.yahoo.com/iranian-exiles-blame-iraqis-camp-death-121733227.html

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Sunday, December 23, 2012

Top tech flops of 2012 tainted a good year for gadgets

34 min.

Molly Klinefelter , Laptop

A lot of good things happened in tech this year.?The iPhone 5 premiered with 4G and a feather-light design. Google released its Nexus 7 tablet to go head-to-head with the Amazon Kindle Fire, and equipped it with Jelly Bean.?Samsung delivered a powerful one-two punch with the Galaxy S III and Galaxy Note II. And we saw a fair number of Ultrabooks that gave the MacBook Air?a run for its money.

But where there?s good, there?s bad. And there were plenty of major tech?fails this year. These awards go to the eight biggest.

Wrong-Way Award: Apple Maps
With all the anticipation surrounding iOS 6, many didn?t think twice about giving up Google Maps for Apple?s new Maps app. But once users switched over, the complaints and outcries that the iOS app was far inferior to Google Maps mushroomed. The app was riddled with errors ? including wrong addresses and warped-looking landmarks in the Flyover view ? while it lacked integrated mass-transit directions.

Apple eventually apologized for the Maps gaffe, and even recommended alternatives. CEO?Tim Cook probably put it best, saying, "We screwed up."

More:?7 Things Apple Must Do in 2013

False Start Award: Windows 8
After Microsoft?released a preview of the highly anticipated Windows 8, users were dismayed to find that, although the new system's classic "desktop" was practically identical to the Windows 7 interface, it lacked a Start menu. Microsoft had substituted the menu with a shortcut to the Start screen, which meant users are forced to leave the desktop just to launch an app that takes them right back to the desktop.

Talk about frustrating. The good news is that a number of third parties have stepped up to the plate with alternatives, including Stardock's Start8 and Samsung's S Launcher utility.

More:?8 Windows 8 Annoyances and How to Fix Them

Worst Sales Pitch: Dell?s ?Daily Deals?
During Laptop's annual Tech Support Showdown, we made three calls to Dell's?tech support line and got more than we bargained for. During the calls, Dell pushed premium warranties on us, saying we had won a daily drawing that would allow us to buy a $500 four-year extended warranty for just $317. Lucky us ? we were chosen to spend even more money on something we didn?t need! When we resisted, the representative rushed us through the call, barely attempting to answer our question, but routinely haranguing us to buy the warranty, because otherwise the next caller would get our "prize."

According to Dell, using "drawings" as a sales tactic is against company policy. However, aggressively pushing extended warranties and hardware purchases is not, as we experienced on two other calls where support reps seemed more interested in making a commission than solving our problems.

More:?Tech Support Showdown 2012

IP-(Uh)-O Award: Facebook
Although Facebook?s IPO initially set a record for technology companies by raising more than $16 billion, it quickly became the decade?s worst initial public offering. When the social networking giant went public in May, its initial offering price was set at $38, while the company was valued at $104 billion. However, a little more than two weeks later, Facebook shares had dropped dramatically to $26.90 per share.

As it turns out, Facebook?s inability to monetize mobile traffic has caused a lot of concern among investors.?Although the stock has rebounded from a recent slide, the share is still way off the debut price.

More:?26 Ultimate Facebook Tips

Biggest Rip-Off Award: Shared Data Plans
In June, Verizon unveiled its new Share Everything plans, which allow customers to pay a flat fee for each device, plus a single charge for shared monthly data, which ranges from 1GB to 10GB. The plan includes unlimited voice minutes and text messages and makes you pay for them, whether you need them or not. As a result, a 2GB data plan costs $100 on the new plan while 2GB with a limited number of minutes and texts cost $70 on the old plan.

AT&T followed suit with similar Mobile Share plans. However, neither of these shared-plan options lets you opt for limited voice minutes or data. Plus, you still need to pay an additional monthly fee as you add devices, whether it?s a tablet?($15 for AT&T, $10 on Verizon Wireless) or mobile hotspot ($50 for AT&T, $20 for Verizon Wireless). At least AT&T kept its individual plans for those who don?t want to go the shared route.

More:?Top 10 Smartphones

Broken Promises Award: BlackBerry?10
BlackBerry 10 has become somewhat of a punchline in the tech industry, with the release of Research?In?Motion?s new mobile?OS continually delayed at a time when the straggling smartphone-maker should be trying anything to keep up with its Android and iPhone?competitors. After a brief demonstration of BlackBerry 10 at BlackBerry World in May, RIM pushed back the operating system?s release until Q1 of 2013, and soon after slashed 5,000 jobs.

Although there are some features in BB10 that look promising, many BlackBerry loyalists have already jumped ship. We'll find out in January if RIM has a shot at a better 2013.

More:?BlackBerry 10 Video Preview

Bait-and-Switch Award: Microsoft Surface
When commercials for the Microsoft?Surface started airing, viewers were enthralled by the device's Touch Cover. It came in fun, eye-catching colors and magnetically snapped onto the device for an easy typing experience.

One would assume that if Microsoft was putting the Touch Cover into its Surface commercials, it would come with the Surface, right? Wrong. Turns out the Touch Cover is a separate purchase, and shoppers would have to invest an additional $119 for the accessory ($100 if you buy it with the black one).

More:?Top 10 Windows 8 Tablet-Laptop Hybrids

Bad Idea Award: Google Nexus Q
Nexus Q could have easily made our list of most overpriced gadgets of all-time ... if it had actually come out. First shown and given to attendees at Google I/O 2012, the Nexus Q is a set-top box in the shape of an orb that streams music and movies to your home theater from Google Play ??and Google Play only.

While a $49 Roku box, a $99 Apple TV or a $99 Google TV box offers a variety of content services, even apps, the $299 Nexus Q didn't even have Netflix. Once you got over its unique design, the Nexus Q's main feature was allowing multiple users to add to the same playlist, something that was sure to create plenty of arguments among family members with different tastes. To Google's credit, the company quickly realized it had a dud on its hands, stopped accepting new orders and gave free units to anyone who had preordered.

More:?The 15 Most Overpriced Gadgets of All Time

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Wednesday, December 19, 2012

Software Development Engineer (SDE) 2 / Microsoft / Redmond, WA

Location: Redmond, WA, US
Job ID: 820216-99863
Division: Windows Division

We are looking for a solid developer who can innovate and develop exciting multimedia technologies for future Windows releases and play a strong role in driving the innovations for future video/image/audio products. Ideal applicants for this job should have a good understanding of signal processing, audio or video compression, and graphics driver models. They should possess solid coding skills, a strong desire to innovate, good presentation and writing skills, and a passion for improving and shipping products. If that?s you, read on!

Windows Multimedia Platform team is responsible for aspects related to audio, video, and images in Windows, including how media is captured, manipulated, stored, rendered/presented, managed inside a PC, and streamed into or from a PC for real-time communications and other connected experiences. Our team delivers the Microsoft Media Platform which primarily includes the Microsoft Media Foundation technology which is used to build the capture, transcode, encode and playback media pipelines. It also includes support for the codecs and other media processing components required for the wide variety of media formats running on a wide variety of systems. We work closely with software and hardware partners to ensure that the media capabilities in Windows function with high performance and quality. Our work is highly visible and very rewarding. You?ll be working in a team of very motivated and passionate people. You?ll have the opportunity to influence decisions that have broad impact across Microsoft, its partners, and hundreds of millions of happy customers around the world.
We also work with GPU IHVs and define the specifications and APIs for offloading complex video decoding, encoding, and processing tasks onto dedicated hardware using DirectX Video Acceleration (DXVA) and Hardware Media Foundation Transforms (MFTs). Working with world renowned team of researchers and developers, you are expected to play a key role in our ongoing and future innovations, besides working on related product development.
We are looking for a solid developer who can innovate and develop exciting multimedia technologies for future Windows releases. We have an immediate opening for a Senior Software Engineer with the following responsibilities and qualifications:
Basic responsibilities:
Define the DDIs for offloading complex video encoding, decoding, and signal processing tasks onto dedicated hardware
Work with IHVs closely to help them to design and deliver next generation content protection modules
Bring up device drivers and deliver performant and efficient systems in close collaboration with IHVs and OEMs
Resolve technical video-related questions or issues that arise as the IHV implements the media functionality.
Basic qualifications:
Solid programming skills, at least 3 years of experience in C/C++
MS or PhD in Computer Science, Computer Eng. or Electrical Eng.
Experience in Audio or Video digital signal processing and compression
Good debugging, instrumenting, profiling, and optimization abilities
Desirables include:
Strong passions in both research and product development
Capability of learning new technologies at a rapid pace from imaging technology, to audio and video compression, to GPGPU programming to Windows platforms
Familiarity with multimedia platforms : Direct Show and Media Foundation
Familiarity with graphic driver model, DirectX, D3D11
Familiarity with ARM, NEON , SSE instructions
Passion to innovate on established and emerging video codec standards/implementations such as H.264 AVC/SVC and H.265 and/or audio codecs.
This is the perfect opportunity for an individual who wants to make a direct impact to Windows product release and at the same time work with great researches on state of the art video technologies.

TO APPLY
Click here to apply - Please mention that you saw the job on VentureBeat

Source: http://feedproxy.google.com/~r/MostHired/~3/uAyBsWCr-y4/

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Tuesday, December 18, 2012

Scientists discover how HIV virus gains access to carrier immune cells to spread infection

Dec. 18, 2012 ? Scientists from the AIDS Research Institute IrsiCaixa have identified how HIV, the virus that causes AIDS, enters the cells of the immune system enabling it to be dispersed throughout an organism. The new study is published December 18 in the open access journal PLOS Biology.

One of the reasons why we do not yet have a cure for HIV infection is that the virus infects cells of the immune system that would normally fight such an infection. The main targets of HIV are white blood cells named CD4 T lymphocytes (so called because they have the protein CD4 in their membrane), and while more than 20 different drugs are available today to help control HIV, all of them act by blocking the cycle that HIV follows to infect these CD4 T lymphocytes. However, these treatments do not fully act on another cell of the immune system, the dendritic cell, which takes up HIV and spreads it to target CD4 T lymphocytes.

Mature dendritic cells are responsible for activating an immune response by CD4 T lymphocytes, but when they carry viruses, their contact with T lymphocytes causes the virus to be passed on, thus increasing viral spread.

The results continue the research led by ICREA researchers at IrsiCaixa, Javier Mart?nez-Picado, and Nuria Izquierdo-Useros, in collaboration with research groups from Heidelberg University, Germany, and the University of Lausanne, Switzerland. This team published a previous PLOS Biology paper in April 2012, in which they identified molecules, called gangliosides, located on the surface of HIV that are recognized by dendritic cells and are necessary for viral uptake. The new results now identify a molecule on the surface of dendritic cells that recognizes and binds the gangliosides and allows HIV to be taken up by dendritic cells and transmitted to its ultimate target: T lymphocytes.

"We have observed that the protein that acts as a lock for the entrance of HIV could also facilitate the entrance of other viruses," explains Nuria Izquierdo-Useros. "Therefore, our results could also help us understand how other infections might exploit this mechanism of dispersion."

In order to identify the precise molecule located on the membrane of the dendritic cells capable of capturing HIV, the researchers studied one family of proteins that are present on the surface of these cells, called Siglecs. It is known that these proteins bind to the gangliosides on the HIV surface. In the laboratory, they mixed the virus with dendritic cells that displayed different quantities of Siglec-1, and found that a higher quantity of Siglec-1 led to those dendritic cells capturing more HIV, which in turn allowed for enhanced transmission of HIV to CD4 T lymphocytes, a process called trans-infection.

The team then tried inhibiting the Siglec-1 protein. Doing so in the laboratory, they found that the dendritic cells lost their capacity to capture HIV and, importantly, they also lost their ability to transfer HIV to CD4 T lymphocytes. With all these data, the scientists concluded that Siglec-1 is the molecule responsible for HIV entrance into the dendritic cells, and could therefore become a new therapeutic target.

"We had the key and now we have found a lock," explains Javier Mart?nez-Picado. "Now we are already working on the development of a drug that could block this process to improve the efficacy of the current existing treatments against AIDS."

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The above story is reprinted from materials provided by Public Library of Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Nuria Izquierdo-Useros, Maier Lorizate, Maria C. Puertas, Maria T. Rodriguez-Plata, Nadine Zangger, Elina Erikson, Maria Pino, Itziar Erkizia, B?rbel Glass, Bonaventura Clotet, Oliver T. Keppler, Amalio Telenti, Hans-Georg Kr?usslich, Javier Martinez-Picado. Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides. PLoS Biology, 2012; 10 (12): e1001448 DOI: 10.1371/journal.pbio.1001448

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/9TZWu_j-r2A/121218203506.htm

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Opposition's Capriles holds seat in Venezuela state elections

(Reuters) - Mourners from close family to complete strangers grieved on Sunday over the loss of 20 children and six adults in a shooting rampage at a Newtown, Connecticut elementary school. Following are snapshots of some of the youngest victims killed on Friday: JACK PINTO, 6, so loved sports that New York Giants receiver Victor Cruz said he was honoring the boy by wearing his name on his cleats and gloves during Sunday's game against the Atlanta Falcons. On Twitter, Cruz posted pictures with "Jack Pinto 'My Hero'" written on one shoe, "R.I.P. ...

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Monday, December 17, 2012

Bangladesh probe: Fire sabotage, owner negligent

DHAKA, Bangladesh (AP) ? A Bangladesh government committee investigating the garment factory fire that killed 112 people last month said in its findings Monday that the blaze was sabotage, probably by someone who worked there.

But the panel said that no matter who set the fire, the owner of the factory also should be punished for the deaths because he neglected worker safety.

"If someone is responsible for such a huge number of deaths, that's him. He has failed to ensure safety," committee head Mainuddin Khandaker said of factory owner Delwar Hossain.

Some government and garment industry officials had alleged soon after the Nov. 24 fire that it was an act of sabotage, though a fire official said casualties would have been greatly reduced if the factory had followed safety rules.

The factory lacked emergency exits and Hossain has said only three floors of the eight-story building were legally built. Surviving employees said gates had been locked and managers had told them to go back to work after the fire alarm went off.

The four-member committee submitted its report to the government Monday. At least two other investigations are continuing.

Khandaker, an official with the Ministry of Home Affairs, told The Associated Press that committee members believe some people who worked at the factory were involved in the sabotage.

"Otherwise, how come they locked the gates? How come they asked the workers to go back to work even after the fire alarm?" he said.

Three factory officials suspected of locking workers inside the building were arrested days after the fire and remain in custody.

Khandaker said the panel recommended further investigation through a "powerful intelligence agency" to unearth the insiders.

No matter who is responsible for setting the fire, Khandaker said, "We can't spare the owner of the factory. He is responsible for his failure to ensure safety. I have recommended specifically to bring the owner under the purview of law."

Hossain "tried to defend himself" under questioning from the committee, Khandaker said. "But I can tell you clearly that he had serious negligence as he has failed to follow existing building code and safety rules."

A phone call seeking comment from Hossain rang unanswered Monday night.

The committee recommended that the government form a "powerful task force" to ensure safety at garment factories across the country. The garment industry accounts for about 80 percent of Bangladesh's exports, and workers' rights groups say existing regulations have gone unenforced because officials fear the industry's power.

The Tazreen Fashions Ltd. factory made clothing for several major U.S. retailers, including Wal-Mart, which had received a 2011 audit warning about the factory's conditions. Wal-Mart and other companies said suppliers had used the Tazreen factory without their knowledge.

Retailers, fashion labels, labor groups and local officials meeting in 2011 in Dhaka, the capital, had discussed an agreement to improve fire safety at Bangladesh's roughly 4,000 garment factories. The proposal went nowhere after a Wal-Mart representative said it was "not financially feasible," according to meeting minutes and witnesses.

Khandaker said the government would now examine his committee's report and take further steps in line with their recommendations.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-12-17-Bangladesh-Factory%20Fire/id-5ccbf404168e4333b4a875ae365c713e

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